What is Hyaluronidase?

Hyaluronidase (Hylase) is an enzyme that breaks down hyaluronic acid, a naturally occurring substance in the skin responsible for hydration and volume. It is widely used in aesthetic medicine to dissolve hyaluronic acid fillers in cases of overfilling, asymmetry, or adverse reactions.

Hyaluronidase hydrolyzes the bonds within hyaluronic acid molecules, allowing for rapid degradation and absorption by the body. This process makes it an essential tool in corrective procedures when patients are dissatisfied with their filler results or experience complications such as vascular occlusion, nodules, or excessive swelling.

Uses of Hyaluronidase in Aesthetic Medicine

• Dissolving hyaluronic acid fillers that have been over-injected or
• Correcting asymmetry or irregularities after dermal filler
• Reversing filler-induced vascular occlusion, a rare but serious
• Reducing excessive swelling or nodules that form after filler
• Adjusting old filler treatments when a patient desires a fresh start before a new

Hyaluronidase Procedure

• Consultation and Assessment – A professional evaluates the area requiring
• Patch Testing (Optional) – Some patients may have allergic reactions to hyaluronidase, so a small test dose may be applied beforehand.
• Injection Process – Hyaluronidase is injected into the target area using a fine needle to dissolve unwanted filler.
• Immediate Action – The enzyme starts breaking down the hyaluronic acid within minutes, with full results appearing within 24-48 hours.
• Follow-up Treatment – If necessary, additional sessions may be scheduled to achieve optimal results.

How Long Does It Take to Work?

• The effect of hyaluronidase can be seen within a few hours, with most of the hyaluronic acid dissolving within 24-48 hours.
• The skin may take a few days to fully recover, and if necessary, new filler injections can be performed after two weeks.

Side Effects and Considerations

• Mild swelling, redness, or bruising at the injection
• Temporary unevenness if filler dissolves
• Possible allergic reaction, though rare, requiring a sensitivity test in some
• Not effective on non-hyaluronic acid fillers, such as calcium hydroxylapatite (Radiesse) or poly-L-lactic acid (Sculptra).